021-51111890
购物车（）
sales@molnova.cn
SB 242084
CAS No. 181632-25-7
SB 242084 ( SB-242084;SB242084 )
产品货号. M12789 CAS No. 181632-25-7
SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥405 | 有现货 |
|
| 5MG | ￥672 | 有现货 |
|
| 10MG | ￥948 | 有现货 |
|
| 25MG | ￥2098 | 有现货 |
|
| 50MG | ￥4026 | 有现货 |
|
| 100MG | ￥6140 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SB 242084
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
-
产品描述SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes; also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors; inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays; potently inhibits m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.
-
同义词SB-242084;SB242084
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Neurological Disease
-
适应症——
化学信息
-
CAS Number181632-25-7
-
分子量467.78
-
分子式C21H19ClN4O2
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 44 mg/mL
-
SMILESCC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C.Cl.Cl
-
化学全称1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Bromidge SM, et al. J Med Chem. 1997 Oct 24;40(22):3494-6.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
产品手册
关联产品
-
Geissoschizine methy...
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist.
-
Eplivanserin
Eplivanserin is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.
-
Niaprazine
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
